CD127 (IL-7Rα) Antigen

The CD127 antigen is a 75-80 kDa type I transmembrane glycoprotein also known as IL-7 receptor α chain or IL-7Rα. It forms a heterodimer with the common γ chain CD132 (IL-2Rγ), which is shared with the receptors for IL-2, IL-4, IL-9, IL-13, IL-15, and IL-21, to form the high affinity IL-7 receptor. CD127 is found on normal B cell precursors but not on mature B lymphocytes. It is also expressed by thymocytes, the majority of peripheral T lymphocytes, a subset of monocytes and a subset of CD34+ cells. CD127 is a useful marker for identifying memory and effector T cells. Its expression is down-modulated on Treg cells. The ligation of IL-7 with its receptor is important for stimulation of mature and immature T cells as well as immature B cell proliferation and development.


 Clone: R34.34  Isotype: IgG1 Mouse

The R34.34 antibody inhibits binding of IL-7 to CD127.
 
 

Choose a CD127 (IL-7Rα) Model

Product Line Specifications

Format Liquid
Specificity CD127
Form FITC
Clone R34.34
Isotype IgG1 Mouse
Cross Reactivity Indian Rhesus, Pigtailed Macaque
Target Species Human
Flow Product Line IOTest
Item Specifications Referenced B25366

The specifications above are not representative of all reagents but only to the item/part number referenced in this Product Line Specifications table. Please view a product's detail page to view all product specifications for that particular reagent. 


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