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Vi-CELL BLU

Automatisierte Bestimmung der Zellzahl, Zellkonzentration und Zellvitalität

Der Vi-CELL BLU setzt neue Maßstäbe in der Bestimmung der Zellzahl, Zellkonzentration und Zellvitalität. Mit nur 200 µl Probenvolumen bietet der Vi-CELL BLU schnelle und reproduzierbare Zellanalysen mittels der Standard-Trypanblau-Methode und modernster digitaler Bildanalyse. Der weltweit einzigartige Wechsel zwischen einer Mikrotiterplatte und einem 24-Positionen-Karussel vereinfach die Messung der Zellzahl, Zellkonzentration und Zellvitalität für Hochdurchsatzlabore signifikant.

Der Vi-CELL BLU automatisiert die Zellanalyse durch automatische Probennahme, über die Anfärbung der Zellsuspension bis hin zur Messung und Reinigung.

Einzigartiger Wechsel zwischen Karussell und Mikrotiterplatte
Nur 200 µl Probenvolumen
21 CFR Part 11 konform
Maximale Bildanzahl: 100
Integrierter Windows 10 Computer

Eigenschaften

Leistungsmerkmale des Vi-CELL BLU

Exakt reproduzierbare Messergebnisse
Probenvolumen Karussell: 200 µl
Probenvolumen Mikrotiterplatte: 200 µl
Messbereich: 2 µm - 60 µm
21 CFR Part 11 konform: Ja
Maximale Bildanzahl: 100

Software

Darstellung von Anzahl-, Konzentration- und Größenverteilung
Ermittlung der Zellvitalität (absolut, % und Zellen /ml)
Ermittlung der Aggregatsanzahl und Aggregatsverteilung

Validierung und Zertifizierung

21 CFR Part 11 konform
Audit-Trail und Passwortschutz
Sicherheitsstufen und elektronische Unterschrift
V-Check Programm für SQ, DQ, IQ, OQ

AutomatischeTrypan-Blau-Methode

Automatisierte Anfärbung und Messung der Zellsuspension
Automatisierte digitale Bildanalyse für die Bestimmung der Zellzahl, Zellkonzentration und Zellvitalität
Analyse von mehr als 15.000 Zellen möglich
Karussell oder Mikrotiterplatte ermöglichen kontinuierliche Messungen

Introducing the Vi-CELL BLU

Spezifikationen

Industry Standards	21 CFR Part 11
Sample Volume Range	0.20\|\|mL
Particle Size Analysis Range	2.00\|60.00\|μm
Sample Volume	200.00\|µL
Concentration Range	50,000.00\|15,000,000.00\|cells/mL

Item Specifications Referenced

C19201

Anwendungshinweise

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Title	Description
Vi-CELL BLU ZELLANALYSATOR {A7DF4F56-8AF9-4BF1-88BE-766AB73FBC6B}	Mit dem Vi-CELL BLU können Sie das standardisierte Verfahren der Trypanblau-Vitalfärbung zur Bestimmung der Zellvitalität automatisieren, für das traditionell Lichtmikroskop, Pipette und Zählkammer nötig waren.
Vi-CELL BLU Cell Viability Analyzer Brochure {A7DF4F56-8AF9-4BF1-88BE-766AB73FBC6B}	Product brochure for the New VI-CELL BLU Cell Viability Analyzer. See what BLU can do for you
Manufacturing Processes for Engineered T-Cell Therapy – CAR-T {749D68FB-4893-4B2D-BD6C-C662F0520F64}	Brochure presenting the CAR-T cell therapy workflow and associated product portfolio
Manufacturing Processes for Engineered T-Cell Therapy – CAR-T	Brochure presenting the CAR-T cell therapy workflow and associated product portfolio
Vi-CELL BLU FAST Mode Option {442DF88C-CA7F-4B78-AF75-9D2B985534C0}	This application note explains the optional FAST Mode of operation in the new Vi-CELL BLU which can be used in either plate or carousel configuration to significantly reduce sample to sample operation times.
Method for Determining Cell Type Parameter Adjustment to Match Legacy Vi-CELL XR {442DF88C-CA7F-4B78-AF75-9D2B985534C0}	This application note assists in matching Vi-CELL BLU cell types to give cell counts and viability levels equivalent to those obtained on existing Vi-CELL XR instruments.
ViCELL BLU and ViCELL XR Specifications	The Vi–CELL BLU leverages the key performance features of the Vi–CELL XR but incorporates many design improvements that our customers have requested over the years. This paper highlights the differences in specifications between the two instruments.
Cell Counting Performance of Vi-CELL BLU Cell Viability Analyzer {442DF88C-CA7F-4B78-AF75-9D2B985534C0}	This application note examines how the new Vi-CELL BLU performs within specifications so that any instrument variability can be eliminated from the sample measurement.
Matching Cell Counts between Vi-CELL XR and Vi-CELL BLU {442DF88C-CA7F-4B78-AF75-9D2B985534C0}	This application note explains the flexibility to adjust the cell type settings to match results obtained from an equivalent sample when run on the Vi-CELL XR on the Vi-CELL BLU.
Considerations of Cell Counting Analysis when using Different Types of Cells {442DF88C-CA7F-4B78-AF75-9D2B985534C0}	This application note reviews several different cell types and cell preparation approaches using standard cells.
Evaluation of Instrument to Instrument Performance of the Vi-CELL BLU Cell Viability Analyzer {442DF88C-CA7F-4B78-AF75-9D2B985534C0}	This application note examines the comparability of results from multiple Vi-CELL BLU cell viability analyzers.
Vi-CELL BLU Regulatory Compliance - 21 CFR Part 11 {442DF88C-CA7F-4B78-AF75-9D2B985534C0}	The following document describes the relevant portions of the 21 CFR Part 11 regulations and their implementation using the Vi-CELL BLU control software.
Vaporized Hydrogen Peroxide Decontamination of Vi-CELL BLU Instrument {442DF88C-CA7F-4B78-AF75-9D2B985534C0}	This application note demonstrates the method and results for testing the Vi-CELL BLU for VHP resistance.
Quality Control Testing Instrumentation Solutions for GMP Manufacturing Brochure {A7DF4F56-8AF9-4BF1-88BE-766AB73FBC6B}	Brochure on Raw Materials QC, Production QC, and Final Product QC product solutions
21 CFR Part 11 QC Instrument Suite {279C6CA2-9797-4CFE-9CAA-5EAFAC29B60D}	This datasheet outlines QC steps, instruments, applications, regulations, and ALCOA compatibility.
ALCOA+ Infographic	Guidance on Maintaining Data Integrity Infographic
Vaporized Hydrogen Peroxide Decontamination of Vi–CELL BLU Instrument <br> {442DF88C-CA7F-4B78-AF75-9D2B985534C0}	Whole instrument decontamination is desirable in many laboratories and necessary in some when using biologically hazardous materials. By necessity such methods are chemically aggressive in nature and can cause serious damage to electronic and optical systems. The Vi–CELL BLU Cell Viability Analyzer was tested for VHP resistance. This paper outlines the method and results.
Matching Cell Counts between Vi–CELL XR and Vi–CELL BLU {442DF88C-CA7F-4B78-AF75-9D2B985534C0}	<p>This paper demonstrates a series of different cell types run on the Vi-CELL XR and duplicate samples run on the Vi-CELL BLU. The cells were then reanalyzed adjusting the cell type parameters until a new cell type was generated that gave cell concentrations within +/–5%* and viable cell density levels within +/–2.5%* of the Vi-CELL XR. </p> <ol> </ol>
Specification Comparison of Vi–CELL XR and Vi–CELL BLU {442DF88C-CA7F-4B78-AF75-9D2B985534C0}	The Vi–CELL BLU leverages the key performance features of the Vi–CELL XR but incorporates many design improvements that our customers have requested over the years. This paper highlights the differences in specifications between the two instruments.
Considerations of Cell Counting Analysis when using Different Types of Cells {442DF88C-CA7F-4B78-AF75-9D2B985534C0}	This paper reviews several different cell types and cell preparation approaches using standard cells, such as, CHO cells, EL4 cells, SF9 cells, and HELA cell cultures.
Cell Counting Performance of Vi–Cell BLU Cell Viability Analyzer {442DF88C-CA7F-4B78-AF75-9D2B985534C0}	To determine the cell counting performance of the Vi–CELL BLU we adapted the protocol outline by NIST to determine the performance of the new Vi–Cell BLU Cell Viability Analyzer.
Method for Determining Cell Type Parameter Adjustment to Match Legacy Vi CELL XR {442DF88C-CA7F-4B78-AF75-9D2B985534C0}	This application note details how you can use the plate loader feature on the Vi-CELL BLU to match cell types to give cell counts and viability levels equivalent to those obtained on existing Vi-CELL XR instruments.
Vi–CELL BLU FAST Mode Option<br> <br> {442DF88C-CA7F-4B78-AF75-9D2B985534C0}	This paper explains the optional FAST Mode of operation in the Vi-CELL BLU cell viability analyzer which can be used in either plate or carousel configuration to significantly reduce sample to sample operation times. <br>
Vi-CELL BLU Regulatory Compliance - 21 CFR Part 11 {442DF88C-CA7F-4B78-AF75-9D2B985534C0}	The following information describes the relevant portions of the 21 CFR Part 11 regulations and their implementation using the Vi-CELL BLU control software.
Evaluation of Instrument to Instrument Performance of the Vi-CELL BLU Cell Viability Analyzer {442DF88C-CA7F-4B78-AF75-9D2B985534C0}
FDA ALCOA Guidance	21 CFR part 11 ALCOA defines good data integrity practice as creating records that are attributable to the technician carrying out the testing, are legible, are created contemporaneously, original and accurate.

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Vi-CELL BLU

Automatisierte Bestimmung der Zellzahl, Zellkonzentration und Zellvitalität