CD158i Antigen

The CD158i molecule (also known as p50.3) is a monomeric integral membrane glycoprotein of 50 kDa. This protein belongs to the family of NK receptors for MHC class I molecules. There is another comprehensive nomenclature which refers to this molecule as KIR2DS4; this acronym stands for Killer cell Immunoglobulin (Ig)-like Receptor (KIR), with extracellular part containing 2 Ig domains (2D), and a short (S) cytoplasmic tail. CD158i comprises 2 C-type extracellular Ig domains. The intracytoplasmic portion lacks characteristic ITIM motifs (Immunoreceptor Tyrosine-based Inhibition Motif) and displays a charged residue in the trans-membrane portion.  CD158i receptor seems involved in NK cell activation, following HLA-Cw3 supertype recognition. Antibody-induced cross-linking of CD158i (p50.3) results in both early activation events and late effector function.


 Clone: FES172  Isotype: IgG2a Mouse

The FES172 antibody stains NK subsets, but the p50.3 antigen appears to be expressed only by some individuals, and to be co-expressed with p58 KIRs.
 

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Product Line Specifications

Format Liquid
Specificity CD158i
Form APC
Clone FES172
Isotype IgG2a Mouse
Target Species Human
Flow Product Line IOTest
Item Specifications Referenced A60796

The specifications above are not representative of all reagents but only to the item/part number referenced in this Product Line Specifications table. Please view a product's detail page to view all product specifications for that particular reagent. 


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