CD208 (DC-LAMP) Antigen
The DC-LAMP antigen (70-90 kDa) is a new member of the LAMP (lysosome-associated membrane protein) family. As other LAMP members such as CD68, DC-LAMP is a type I integral membrane protein of 416 amino acid residues, highly glycosylated (7 N- and some O-glycosylation sites), with 90% of the molecule located in the lumen of lysosomes. DC-LAMP is specifically expressed by those mature dendritic cells (DC) located in T cell areas of lymphoid tissues, which are known as interdigitating dendritic cells (IDC). A direct correlation between the expression of DC-LAMP and that of other maturation markers such as CD86 has been established. DC-LAMP first appears in the MHC Class II compartment, suggesting an important contribution of DC-LAMP to the processing of exogenous antigens.
|Clone: 104.G4||Isotype: IgG1 Mouse|
|In flow cytometry, the 104.G4 antibody shows intracytoplasmic staining of DCs derived either from CD34+ cell cultures activated with TNFα and CD40L, or from monocyte cultures activated with TNFα, LPS and CD40L.
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Product Line Specifications
|Item Specifications Referenced||IM3448|
The specifications above are not representative of all reagents but only to the item/part number referenced in this Product Line Specifications table. Please view a product's detail page to view all product specifications for that particular reagent.