Beckman.com is conducting maintenance on its shopping cart Friday, July 10th at 9 pm PST thru Sunday, July 12th at 10 pm PST. During this time, orders can still be placed by calling Client Services. We look forward to providing you an improved shopping experience.
The CD40 antigen is a 44-48 kDa type I integral membrane protein of the tumor necrosis factor receptor (TNFR) superfamily. This antigen is found on B cell lines, is strongly expressed by interdigitating cells (IDC), basal epithelial cells, and is also present on macrophages, some endothelial cells, and follicular dendritic cells. It is a pan-B marker, absent only from terminally differentiated plasma cells. CD40 is implicated in the process of B cell selection in the germinal centre. Studies demonstrated that CD40 monoclonal antibodies (mAbs) induce strong homotypic adhesions in resting B cells and, together with interleukin-4 (IL-4) maintain the cell cycle of blasts of the B lineage. They also can promote the switch to IgE secretion. Activated B cells via CD40 antigen in the presence of IL-10 differentiate into plasma cells and secrete large amounts of immunoglobulins. The CD154, (CD40 ligand) is a membrane glycoprotein on activated T cells that induces B cell proliferation and immunoglobulin secretion. CD154 is also expressed on activated platelets and triggers an inflammatory reaction of endothelial cells.
Isotype: IgG1 Mouse
Co-culture with MAB89 and IL-4 leads to long term B cell proliferation.
The specifications above are not representative of all reagents but only to the item/part number referenced in this Product Line Specifications table. Please view a product's detail page to view all product specifications for that particular reagent.
There are currently no Technical Documents associated with this page or product. Please try our Technical Documents search
Related Products or Parts
Oops. The page you wanted could not be found, so we brought you to something similar. If you still can't find what you want, try searching our site instead.