Beckman.com is conducting maintenance on its shopping cart Friday, July 10th at 9 pm PST thru Sunday, July 12th at 10 pm PST. During this time, orders can still be placed by calling Client Services. We look forward to providing you an improved shopping experience.
OSCAR, an abbreviation of osteoclast-associated receptor, is a new member of the leukocyte receptor complex. Human OSCAR is a cell-surface, monomeric N-glycosylated protein of approximately 45 kDa. The amino acid sequence shows homology with that of members of the KIR family. The protein exhibits two C2-type immunoglobulin extracellular domains, a transmembrane section that contains a positively charged arginine residue, and a short intracytoplasmic tail with no recognizable signaling motif. As suggested by the presence of the charged residue, OSCAR associates with the ITAM-adapter FcRγ and not with other signaling molecules. The gene coding for OSCAR has been mapped to chromosome 19q13. Unlike mouse OSCAR, human OSCAR is widely expressed in cells of the myeloid lineage, and in particular, at all stages of dendritic cell (DC) differentiation and maturation. T cells, B cells, and NK cells do not express OSCAR. OSCAR is involved in antigen presentation and activation of human DCs. It allows processing and presentation of exogenous antigens.
The specifications above are not representative of all reagents but only to the item/part number referenced in this Product Line Specifications table. Please view a product's detail page to view all product specifications for that particular reagent.
There are currently no Technical Documents associated with this page or product. Please try our Technical Documents search
Related Products or Parts
No Data Available
No Data Available
Oops. The page you wanted could not be found, so we brought you to something similar. If you still can't find what you want, try searching our site instead.