What are adeno-associated viruses (AAVs) and why are they used as vectors?
AAVs can stably infect both dividing and non-dividing cells, and this, combined with the wild-type virus’s lack of pathogenicity makes AAVs an attractive choice for research and therapeutic gene transfer approaches. However, AAVs are highly immunogenic, and many individuals possess pre-existing antibodies against AAVs from prior infection.1 For further expansion on related areas and topics please visit viral vectors in our resource center here.
1. S. Daya and K.I. Berns, “Gene Therapy Using Adeno-Associated Virus Vectors,” Clin Microbiol Rev 21(4): 583-593, 2008.