Beckman Coulter Life Sciences is taking actions in the best interests of our associates, customers, and business partners as we navigate the growing threats of the 2019 Novel Coronavirus disease (COVID-19). Learn more
Chimeric antigen receptors (CARs) are synthetically engineered recombinant receptors. In T cells, they represent a single receptor capable of facilitating both antigen binding/recognition and T cell activation.1 Incorporating both of these signals into a single receptor reduces the number of interactions required for T cell activation and prevents cancer cells from exploiting single signal-based T cell inactivation mechanisms.
1. M. Sadelain, et al., “The basic principles of chimeric antigen receptor design,” Cancer Discov 3(4):388-398, 2013.
Oops. The page you wanted could not be found, so we brought you to something similar. If you still can't find what you want, try searching our site instead.