TNF Alpha Antigen

Tumor necrosis factor α (TNFα) or cachectin is a cytokine that was first identified based on its cytotoxic activity against various cell lines and tumor cells. Human TNFα is synthesized as a pro-protein with a molecular weight of 26 kDa (membrane-bound form). The pro-protein is cleaved by a specific metalloprotease (TACE) yielding a monomeric, soluble form of 17 kDa. Under physiological conditions, TNFα forms a homotrimeric protein. This cytokine is primarily produced by mononuclear phagocytes, and by activated lymphocytes. Immunostaining allows intracellular detection of TNFα before it can be detected by a bioassay. TNFα acts on target cells by binding to two types of receptors, the TNFα receptor I (TNF-RI or CD120a) and the TNFα receptor II (TNF-RII or CD120b). TNFα elicits a wide spectrum of immune and inflammatory responses, including the induction of other cytokines and immunoregulatory molecules, cell growth and differentiation and apoptosis. This molecule is also involved in Th1 - Th2 (T helper 1 - T helper 2) cytokine pathways (or Type 1 - Type 2 responses), as a Th1-effector cytokine.


 Clone: IPM2 (188)  Isotype: IgG1 Mouse

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Product Line Specifications

Format Liquid
Specificity TNFα
Form PE
Clone IPM2
Isotype IgG1 Mouse
Target Species Human
Flow Product Line IOTest
Item Specifications Referenced IM3279U

The specifications above are not representative of all reagents but only to the item/part number referenced in this Product Line Specifications table. Please view a product's detail page to view all product specifications for that particular reagent. 


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