Comparing Traditional Aggregation Measurement Techniques to the Valita Aggregation Pure Assay

Aggregation is considered one of the key critical quality attributes (CQA) associated with monoclonal antibodies, especially in process development when thorough assessment of aggregation is crucial.

Preventing protein aggregation in a timely manner is of great importance to the biopharmaceutical industry. However, certain methods like DLS/SLS and HPLC-SEC can take hours to produce results due to longer processing times and lower throughput. When dealing with hundreds or thousands of samples to create a commercially viable cell line, these hours accumulate and add unnecessary complexity to your workflow, ultimately affecting your time to market.

Fortunately, there’s a better way. The Valita Aggregation Pure assay is one of the fastest, easiest, and automatable protein aggregation quantification assays available. In just three simple steps and as little as 15 minutes, you can prepare and measure a full 96-well plate.

Valita Aggregation Pure assay compared to HPLC-SEC and DLS/SLS

 

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The Valita Aggregation Pure Assay vs. HPLC-SEC

When comparing the performance of the Valita Aggregation Pure assay to HPLC-SEC, it becomes obvious that both methods demonstrate a high correlation with each other. The same level of accuracy can still be expected from the Valita Aggregation Pure assay as with the existing method, but with an enhanced throughput and a faster, simpler workflow.


Ranking: Valita Aggregation Pure assay vs HPLC-SEC

table comparing Valita Aggregation Pure assay vs HPLC-SEC

 

% Aggregation: Valita Aggregation Pure assay vs HPLC-SEC

table comparing % aggregation in Valita Aggregation Pure assay vs HPLC-SEC

 

Ranking: Valita Aggregation Pure assay vs HPLC-SEC

table comparing ranking in Valita Aggregation Pure assay vs HPLC-SEC

 

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Insightful Resources

valitatiter application note
 
Application Note
The Valita Aggregation Pure assay: A rapid and accurate alternative for aggregation quantification of purified monoclonal antibodies

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Brochure
Valita Aggregation Pure Assay Brochure

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