Automated Solutions for Cell Line Development
Your Guide to Workflow Intelligence
Product Solutions
Biomek i7 Automated Workstation
Improve procedural ELISA, achieve single cell suspension reliably, simplify transfection optimization, and adapt basic cell culture workflows.
- Extend production scale and centralize operations
- Leverage dual-arm pipetting
- Flexibility with reagent and media mixing, and cell passaging and plating
- Improve efficiency by directly integrating required components
- Simplify serial dilutions with built-in spanning transfer system
- Improve analysis efficiency with sample and data tracking*
- Take control of multi-day planning*
- Monitor progress with platform status light
- Remote system monitoring using on-deck cameras
*Possible through optional software packages DART and SAMI.
Orbital Shaker
Promote cell health with user-definable and reliable agitation of microplates, cultured cells, or general vortexing.- Smooth and continuous motion, enabling nutrient diffusion without splashing
- Timed oribtal and pulse shaking
- Ramped acceleration/deceleration
- Shaking speed ranges from 100 rpm to 1800 rpm
- Space saving
- Easily integrated with Biomek i7
- Increases experimental flexibility
Reagent Dispensers
Accelerate assay-specific or maintenance laboratory protocols with automated, precise dispensing. Ensure the accuracy of reagent dispense volumes.- Simplify workflows
- Dispense a wide range of volumes
- Minimize contamination
- Interchangeable dispensing heads available
- Increase accuracy
- Superior mixing
- Reduce air bubble formation
- Integrates with Biomek i7
- Flexibility to configure reagent containers of wide-ranging volumes
Automated Labware Positioners (ALPs)
Workstation-integrated and interchangeable components that perform specific tasks. ALPs make it possible to configure the platform for accommodation of a wide range of applications.Peltier
- Shaking model shakes microplates at speeds ranging from 100 rpm to 1400 rpm
- Temperature control capable
Tilting ALP
- Controlled and gentle media exchange
- Media is removed from edge of well without disturbing adherent cells
Incubator
An incubator provides a consistent environment for the housing of growing cell cultures and for the temporary incubation of cells underdoing experimental assays.- Temperature can range from 4° C to 70° C, with a relative high humidity (RH) of up to 98% stable CO2 conditions, and shaking
- Mammalian cell conditions: 37° C, 95% RH, and 5% CO2
- A Biomek i7 integration with an incubator eliminates recovery loss and reduces assay variance
- Increase throughput
- Streamline long-term cell culture processes
- Eliminate manual, repeated accessing of cells
Vi-CELL BLU
Eliminate human error and user bias when counting cells and determining viability.- Automated solution for Trypan Blue viability assays
- Analyze mammalian, insect, and yeast cell types (2–70 microns)
- Clumpy samples can be differentiated in number and viability
- Quickly and reliably assess cell shape, size, growth rate, and doubling time
- Enhance statistical reliability
- Convenient reagent kit, concentration control, and sample cups
- Viable cells are outlined in green and nonviable in red:
CloneSelect™ Imager
Rapidly and objectively monitor cell growth, verify cell line monoclonality, and normalize measurements specific to cell productivity.
- Ultra-fast benchtop imaging system for:
- Confluence measurement
- Growth curve generation
- Cell number estimation
- Monoclonality verification
- Colony forming assays
- Cytotoxicity assays
- Cell migration assays
- Consistent results in less time
- Saves all images and generated data
- Integrates with Biomek i7 workstation
“CloneSelect Imager has become an essential system for verification of monoclonality within our cell line development workflow.”
− Dr. Howard Clarke, Process Development, CMC ICOS Biologics Inc., USA
ValitaTiter
ValitaTiter is a plate based, 96 and 384-well assay that offers a rapid, cost effective way to measure IgG.
Robotic Arm
Offers dependable precision and flexibility that not only increases useable workspace, but reliably operates around the clock to eliminate human variability.
- Multiple axis points can reach peripheral equipment
- Walk away capability increases personnel productivity
- Accelerates time to results
- Enhance data reproducibility
- Improve laboratory ergonomics
- Integrates with Biomek i7
Capper/Decapper
Hands-free automated capping and decapping technology ensures sample protection, wholeness, and quality.
- Cap tubes to optimal torque
- Reliably increase throughput
- Improve laboratory ergonomics
- Benchtop or integrated use
- Internal controls prevent contamination and debris introduction
Robotic Shuttle
Controlled robotic plate management with a customizable conveyor track assists with handling consistency and eliminates human-induced accidents.
- Conveyor transports plates from location the Biomek deck to off deck components within the workstation
- Allows for simultaneous transports on and off deck for maximum efficiency
- Streamlines workflow for maximum productivity
Avanti JXN
High-Speed Centrifuge
Enhance isolation and purification workflows for a variety of bioproduction needs.
- Friction reduction system (FRS) for quicker, quieter, and cooler runs
- Shorter cycle times with high-torque and switched reluctance (SR) drive cycle
- Remote run setup and monitoring
- Hands-free door operation
- Track and control usage and samples
- Efficient, safe workflow matches industry compliance
Workflow Solutions
Learn about the solutions for each critical step of the process of developing a mammalian cell line for recombinant protein manufacturing using a methotrexate (MTX) amplification system, one of many integrated transfection methods by Beckman Coulter.
Automation can increase efficiency and consistency in selecting high producing cells with desired Critical Quality Attributes.
Cell Line Engineering
Optimal host cell transfection is dependent on cell health, degree of confluency, DNA quality and quantity, number of passages, contamination, and transfection reagent or method. OUR SOLUTIONS:
Biomek i7 Automated Workstation
- Preparation of transfection reagents, addition of expression plasmid and transfection reagents
- Cell plating, handling, and maintenance minimize human error, enhancing reproducibility and enabling continuous production
Vi-CELL BLU Cell Viability Analyzer
- Count and image cells
- Stain cells and measure viability
Reagent Dispenser
- Configure reagent containers of wide-ranging volumes
Robotic Arm
- Moves plates between workstation and analyzer
Cell Line Characterization
Select colonies by sub-cloning, which includes performing multiple rounds of serial dilution to identify the most stable and highest-producing single cell clone. This step is labor intensive and requires weeks to complete.
OUR SOLUTIONS:
CloneSelect™ Imager
- Verify monoclonality
- Optimize and monitor clonal outgrowth
Biomek i7 Automated Workstation
- Cell-plating, handling, maintenance, and hitpicking
Automated Labware Positioners (ALPs)
- Perform application-specific or general tasks to expedite protocols
Reagent Dispenser
- Configure to dispense reagents from different containers and wide-ranging volumes
Robotic Arm
- Moves plates to/from workstation, incubator*
Cell Line Characterization
Expand the clone producing your desired protein to begin the process development and optimization stage. Certifying clone productivity and quality is fundamental to efficient cell line scale up. Maintaining cell culture health and stable production are common pitfalls during this step. OUR SOLUTIONS:
Vi-CELL Cell Viability Analyzer
- Count and image cells
- Stain cells and measure viability
Biomek i7 Automated Workstation
- Hit picking and seeding
Robotic Arm
- Moves plates to/from workstation and analyzer
Robotic Shuttle
- Conveyor track eliminates human-induced mishaps during transport
- Speed and acceleration can be controlled to prevent splashing in larger-well plates
Avanti JXN High-Speed Centrifuge
- Isolate and purify products reliably and efficiently
Process Development
As you scale up, media optimization will enable maximize protein production. An ideal approach is using a factorial design of experiment (DOE), where a variety of media components are tested at different concentrations in combination with one another. Automation of DOE eliminates any sample preparation beyond an optional dilution step and the high throughput models can process up to 96 samples simultaneously.
OUR SOLUTIONS:
Biomek i7 Automated Workstation
- Tight control of media dispensing volumes
- Gentle cell handling through controlled speed prevents cell shearing and damage
- DOE optimization with multi-channel selection tip
ValitaTiter
- Measures IgG
CloneSelect™ Imager
- Monitor cell growth
Reagent Dispenser
- Configure reagent containers of wide-ranging volumes
Biomek Automated Workstations are not intended or validated for use in the diagnosis of disease or other conditions. Beckman Coulter Life Sciences genomic reagent kits are for research US only.
Helpful Links
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Online Datenarchiv
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Application Notes
- 17-Marker, 18-Color Human Blood Phenotyping Made Easy with Flow Cytometry
- 21 CFR Part 11 Data Integrity for On-line WFI Instruments
- 8011+ Reporting Standards Feature and Synopsis
- A High-Throughput, Automated Screening Platform for IgG Quantification During Drug Discovery and Development
- The Valita Aggregation Pure assay: A rapid and accurate alternative for aggregation quantification of purified monoclonal antibodies
- Achieving Compliant Batch Release – Sterile Parenteral Quality Control
- Air Particle Monitoring ISO 21501-4 Impact
- An Analytical Revolution: Introducing the Next Generation Optima AUC
- Analyzing Mussel/Mollusk Propagation using the Multisizer 4e Coulter Counter
- Automated 3D Cell Culture and Screening by Imaging and Flow Cytometry
- Automated Cell Transfection and Reporter Gene Assay
- Automated Cord Blood Cell Viability and Concentration Measurements Using the Vi‑CELL XR
- Automated salt-assisted liquid-liquid extraction
- Automated Sample Preparation for the Monitoring of Pharmaceutical and Illicit Drugs by LC-MS/MS
- Automated XTT Assay for Cell Viability Analysis
- Automating Biopharma Quality Control to Reduce Costs and Improve Data Integrity
- Automating Bradford Assays
- Automating Cell-Based Processes
- Automating Cell Line Development
- Leveraging the Vi-CELL MetaFLEX for Monitoring Cell Metabolic Activity
- Avanti J-15 Centrifuge Improves Sample Protection Maximizes Sample Recovery
- The New Avanti J-15 Centrifuge Time Saving Deceleration Profile Improves Workflow Efficiency
- Avanti JXN Protein Purification Workflow
- Avoid the Pitfalls When Automating Cell Viability Counting for Biopharmaceutical Quality Control
- Beer, Evaluation of Final Product and Filtration Efficiency
- Biomek Automated NGS Solutions Accelerate Genomic Research
- Biomek i-Series Automated IDT® xGen Hybridization Capture of DNA libraries on Biomek i7 Hybrid Genomics Workstation
- Biomek i-Series Automated Illumina® Nextera XT DNA Library Prep Kit
- Biomek i-Series Automated Illumina TruSeq DNA PCR-Free Library Prep Kit
- Biomek i-Series Automated Illumina TruSeq® Nano DNA Library Prep Kit
- Biomek i-Series Automated Illumina TruSeq® Stranded mRNA Sample Preparation Kit Protocol
- Biomek i-Series Automated Illumina TruSeq® Stranded Total RNA Sample Preparation Kit Protocol
- Biomek i–Series Automated Illumina® TruSight Tumor 170 32 Sample Method
- Biomek i-Series Automated KAPA HyperPrep and HyperPlus Workflows
- Biomek i-Series Automated New England Biolabs NEBNext® Ultra IITM DNA Library Prep Kit
- Biomek i-Series Automated Promega Wizard MagneSil Tfx™ Plasmid Purification System
- Biomek i-Series Automated SurePlex PCR and VeriSeq PGS Library Prep for Illumina®
- Biomek i-Series Automation of the Beckman Coulter Agencourt DNAdvance Genomic DNA isolation Kit
- Biomek i-Series Automation of the Beckman Coulter GenFind V3 Blood and Serum DNA Isolation Kit
- Preparation and purification of carbon nanotubes using an ultracentrifuge and automatic dispensing apparatus, and analysis using an analytical centrifuge system
- Cell Counting Performance of Vi–Cell BLU Cell Viability Analyzer
- Cell Culture Monitoring with the Vi-CELL MetaFLEX
- Viability Assessment of Cell Cultures Using the CytoFLEX
- Cell Line Development – Data Handling
- Cell Line Development – Limiting Dilution
- Cell Line Development – Selection and Enrichment
- Cellular Analysis using the Coulter Principle
- Changes to GMP Force Cleanroom Re-Classifications
- Characterizing Insulin as a Biopharmaceutical Using Analytical Ultracentrifugation
- Classifying a Small Cleanroom using the MET ONE HHPC 6+
- Clean Cabinet Air Particle Evaluation
- Recommended cleaning procedure for the exterior surface of the MET ONE 3400+
- Cleanroom Routine Environmental Monitoring – FDA Guidance on 21 CFR Part 11 Data Integrity
- Cluster Count Analysis and Sample Preparation Considerations for the Vi-CELL BLU Cell Viability Analyzer
- Comparing Data Quality & Optical Resolution of the Next Generation Optima AUC to the Proven ProteomeLab on a Model Protein System
- Conducting the ISO 14644-3 Cleanroom Recovery Test with the MET ONE 3400+
- Überlegungen zur Zellzählung beim Gebrauch von verschiedenen Zelltypen
- Consistent Cell Maintenance and Plating through Automation
- Control Standards and Method Recommendations for the LS 13 320 XR
- Counting Efficiency: MET ONE Air Particle Counters and Compliance to ISO-21501
- Critical Particle Size Distribution for Cement using Laser Diffraction
- Use Machine Learning Algorithms to Explore the Potential of Your High Dimensional Flow Cytometry Data Example of a 20–color Panel on CytoFLEX LX
- How to use R to rewrite FCS files with different number of channels
- A new approach to nanoscale flow cytometry with the CytoFLEX nano analyzer
- CytoFLEX nano Flow Cytometer: the new frontier of nanoscale Flow Cytometry
- Detecting and counting bacteria with the CytoFLEX research flow cytometer: II-Characterization of a variety of gram-positive bacteria
- Detecting Moisture in Hydraulic Fluid, Oil and Fuels
- Detection of foreign matter in plating solution using Multisizer4e
- Determination of Size and Concentration of Particles in Oils
- Efficient kit-free nucleic acid isolation uses a combination of precipitation and centrifugation separation methods
- dsDNA Quantification with the Echo 525 Liquid Handler for Miniaturized Reaction Volumes, Reduced Sample Input, and Cost Savings
- Compensation Setup For High Content DURAClone Reagents
- Echo System-Enhanced SMART-Seq v2 for RNA Sequencing
- Efficient Factorial Optimization of Transfection Conditions
- Enhancing Vaccine Development and Production
- Enumeration And Size Distribution Of Yeast Cells In The Brewing Industry
- European Pharmacopoeia EP 2.2.44 and Total Organic Carbon
- Evaluation of Instrument to Instrument Performance of the Vi-CELL BLU Cell Viability Analyzer
- Exosome-Depleted FBS Using Beckman Coulter Centrifugation: The cost-effective, Consistent choice
- Flexible ELISA automation with the Biomek i5 Workstation
- Friction Reduction System High Performance
- Fully Automated Determination of Benzodiazepines
- Fully Automated Determination of Cannabinoids
- Fully Automated Removal Cartridges
- Leveraging the Vi-CELL MetaFLEX for Monitoring Cell Metabolic Activity
- Get Control in GMP Environments
- Getting Started with Kaluza: Parameters
- g-Max: Added Capabilities to Beckman Coulter's versatile Ultracentrifuge Line
- Grading of nanocellulose using a centrifuge
- A method of grading nanoparticles using ultracentrifugation in order to determine the accurate particle diameter
- Grading of pigment ink and measurement of particle diameter using ultracentrifugation / dynamic light scattering
- HIAC Industrial – Our overview solution for fluid power testing for all applications
- A complete workflow for high-throughput isolation of DNA and RNA from FFPE samples using Formapure XL Total on the KingFisher™ Sample Purification System: an application for robust and scalable cancer research and biomarker discovery
- High-Throughput qPCR and RT-qPCR Workflows
- A Highly Consistent BCA Assay on Biomek i-Series
- A Highly Consistent Bradford Assay on Biomek i-Series
- A Highly Consistent Lowry Method on Biomek i-Series
- Highly Reproducible Automated Proteomics Sample Preparation on Biomek i-Series
- High-throughput Miniaturization of Cytochrome P450 Time-dependent Inhibition Screening Using the Echo 525 Liquid Handler
- Cell Line Development – Hit Picking
- How to Use Violet Laser Side Scatter Detect Nanoparticle
- How Violet Side Scatter Enables Nanoparticle Detection
- HRLD Recommended Volume Setting
- Automating the Cell Line Development Workflow
- ICH Q2 – the Challenge of Measuring Total Organic Carbon in Modern Pharmaceutical Water Systems
- ICH Q2 – The Challenge of Measuring Total Organic Carbon in Modern Pharmaceutical Water Systems
- Illumina Nextera Flex for Enrichment on the Biomek i7 Hybrid Genomics Workstation
- Importance of TOC measurement in WFI in light of European Pharmacopoeia change
- Improved data quality of plate-based IgG quantification using Spark®’s enhanced optics
- Integration of the Vi-CELL BLU Cell Viability Analyzer into the Sartorius Ambr® 250 High Throughput for automated determination of cell concentration and viability
- Temperature dependence of hydrodynamic radius of an intrinsically disordered protein measured in the Optima AUC analytical ultracentrifuge.
- Issues with Testing Jet Fuels for Contamination
- Jurkat Cell Analyses Using the Vi-CELL BLU Cell Viability Analyzer
- Leveraging the Vi-CELL MetaFLEX for Monitoring Cell Metabolic Activity
- Linearity of BSA Using Absorbance & Interference Optics
- Long Life Lasers
- LS 13 320 XR: Sample Preparation - How to measure success
- Partikelgrössenanalyse einfach, aber effektiv und präzise
- Beckman’s LS 13 320 XR Vs. Malvern Mastersizer
- Verwenden von Algorithmen für maschinelles Lernen, um einen tiefen Einblick in die Zusammensetzung von Zellsubpopulationen zu erhalten
- Flow Cytometric Analysis of auto-fluorescent cells found in the marine demosponge Clathria prolifera
- Abgleich von Zellzählungsergebnissen zwischen Vi–CELL XR und Vi–CELL BLU
- MET ONE 3400+ LDAP & Active Directory connection Guide
- MET ONE Sensor Verification
- Metal colloid purification and concentration using ultracentrifugation
- Separation and purification of metal nanorods using density gradient centrifugation
- Method for Determining Cell Type Parameter Adjustment to Match Legacy Vi CELL XR
- Migration of Panels Designed on the CytoFLEX S Flow Cytometer to CytoFLEX SRT Cell Sorter
- High-throughput Miniaturization of Cytochrome P450 Time-dependent Inhibition Screening Using the Echo 525 Liquid Handler
- Miniaturization and Rapid Processing of TXTL Reactions Using Acoustic Liquid Handling
- Miniaturized Enzymatic Assays with Glycerol
- Miniaturized and High-Throughput Metabolic Stability Assay Enabled by the Echo Liquid Handler
- Miniaturized Multi-Piece DNA Assembly Using the Echo 525 Liquid Handler
- Miniaturized Sequencing Workflows for Microbiome and Metagenomic Studies
- Minimal Sample to Sample Carry Over with the HIAC 8011+
- Minimizing process variability in the manufacturing of bottled drinking water
- Modern Trends in Non‐Viable Particle Monitoring during Aseptic Processing
- Multi-Wavelength Analytical Ultracentrifugation of Human Serum Albumin complexed with Porphyrin
- Particle diameter measurement of a nanoparticle composite - Using density gradient ultracentrifugation and dynamic light scattering
- Nanoscale Sorting with the CytoFLEX SRT Cell Sorter
- Identification of Circulating Myeloid Cell Populations in NLRP3 Null Mice
- What to do now that ACFTD is discontinued
- Optimizing the HIAC 8011+ Particle Counter for Analyzing Viscous Fluids
- Optimizing the Multisizer 4e Coutler Counter for use with Small Apertures
- Optimizing Workflow Efficiency of Cleanroom Routine Environmental Monitoring
- Particle Counting in Mining Applications
- Particle testing in cleanroom high-pressure gas lines to ISO 14644 made easy with the MET ONE 3400 gas calibrations
- PCR Reaction Setup and AMPure XP Application
- PCR Reaction Setup Application
- Pharma Manufacturing Environmental Monitoring
- Pharma Manufacturing Paperless Monitoring
- Analysis of plant genome sizes using flow cytometry: a case study demonstrating dynamic range and measurement linearity
- Plate Deposition Speed Comparison of Astrios and CytoFLEX SRT Cell Sorters
- Flow Cytometric Approach to Probiotic Cell Counting and Analysis
- Purifying viral vector with VTi 90 rotor and CsCl DGUC
- Calibrating the QbD1200 TOC Analyzer
- Detection Limit
- JP SDBS Validation
- USP System Suitability
- Quality Control Electronic Records for 21 CFR part 11 Compliance
- Using the Coulter Principle to Quantify Particles in an Electrolytic Solution for Copper Acid Plating
- A Rapid Flow Cytometry Data Analysis Workflow Using Machine Learning- Assisted Analysis to Facilitate Identifying Treatment- Induced Changes
- Rapid Measurement of IgG Using Fluorescence Polarization
- Leveraging the Vi-CELL MetaFLEX for Monitoring Cell Metabolic Activity
- Root Cause Investigations for Pharmaceutical Water Systems
- Single Cell Sorting with CytoFLEX SRT Cell Sorter
- Full Automation of the SISCAPA® Workflow using a Biomek NXP Laboratory Automation Workstation
- Sorting Rare E-SLAM Hematopoietic Stem Cells Using CytoFLEX SRT and Subsequent Culture
- Specification Comparison of Vi–CELL XR and Vi–CELL BLU
- Specifying Non-Viable Particle Monitoring for Aseptic Processing
- A Standardized, Automated Approach For Exosome Isolation And Characterization Using Beckman Coulter Instrumentation
- Streamlined Synthetic Biology with Acoustic Liquid Handling
- Switching from Oil Testing to Water and back using the HIAC 8011+ and HIAC PODS+
- Advanced analysis of human T cell subsets on the CytoFLEX flow cytometer using a 13 color tube-based DURAClone dry reagent
- Comparative Performance Analysis of CHO and HEK Cells Using Vi-CELL BLU Analyzer and Roche Cedex® HiRes Analyzer
- Using k-Factor to Compare Rotor Efficiency
- Validation of On-line Total Organic Carbon Analysers for Release Testing Using ICH Q2
- Vesicle Flow Cytometry with the CytoFLEX
- Variability Analysis of the Vi-CELL BLU Cell Viability Analyzer against 3 Automated Cell Counting Devices and the Manual Method
- Vi–CELL BLU im Fast Mode
- Vi-CELL BLU Regulatory Compliance - 21 CFR Part 11
- A fully automated plate-based optimization of fed-batch culture conditions for monoclonal antibody-producing CHO cell line
- Adaptive Laboratory Evolution of Pseudomonas putida in the RoboLector
- Automated Research Flow Cytometry Workflow Using DURA Innovations Dry Reagent Technology with the *Biomek i7 Automated Workstation and *CytoFLEX LX Flow Cytometer
- Automating antibody titration using a CytoFLEX LX analyzer Integrated with a Biomek i7 Multichannel workstation and Cytobank streamlined data analysis
- Automated IDT Alt-R CRISPR/Cas9 Ribonucleoprotein Lipofection Using the Biomek i7 Hybrid Automated Workstation
- Automation of protein A ELISA Assays using Biomek i7 hybrid workstation
- Monitoring E. coli Cultures with the BioLector and Multisizer 4e Instruments
- Monitoring Yeast Cultures with the BioLector and Multisizer 4e instruments
- Biomek i7 Hybrid Automated KAPA mRNA HyperPrep Workflow
- Cultivation of suspended plant cells in the BioLector®
- Determination of cell death in the BioLector Microbioreactor
- DO-controlled fed-batch cultivation in the RoboLector®
- Screening of yeast-based nutrients for E. coli-based recombinant protein production using the RoboLector Platform
- E. coli fed-batch cultivation using the BioLector® Pro
- Echo System-Enhanced SMART-Seq v4 for RNA Sequencing
- Filling MicroClime Environmental Lids
- Fully Automated Peptide Desalting for Liquid Chromatography–Tandem Mass Spectrometry Analysis Using Beckman Coulter Biomek i7 Hybrid Workstation
- Getting Started with Kaluza: Data Scaling and Compensation Adjustment
- A Simple Guide to Selecting the Right Handheld Particle Counter for Monitoring Controlled Environments
- High throughput cultivation of the cellulolytic fungus Trichoderma reesei in the BioLector®
- Host Cell Residual DNA Testing in Reduced Volume qPCR Reactions Using Acoustic Liquid Handling
- Linearity of the Vi-CELL BLU Cell Counter and Analyzer
- Media optimization in the RoboLector platform for enhanced protein production using C. glutamicum
- Miniaturization of an Epigenetic AlphaLISA Assay with the Echo Liquid Handler and the BMG LABTECH PHERAstar FS
- Miniaturization of Cytochrome P450 Time-dependent Inhibition Screening Using the Echo 555 Liquid Handler
- Miniaturized 16S rRNA Amplicon Sequencing with the Echo 525 Liquid Handler for Metagenomic and Microbiome Studies
- Miniaturized Enzo Life Sciences HDAC1 Fluor de Lys Assays Using an Echo Liquid Handler Integrated in an Access Laboratory Workstation
- Miniaturized EPIgeneous HTRF Assays Using the Echo Liquid Handler
- Miniaturized Gene Expression in as Little as 250 nL
- Miniaturized Genotyping Reactions Using the Echo Liquid Handler
- Mode of operation of optical sensors for dissolved oxygen and pH value
- Nanoliter Scale High-Throughput Protein Crystallography Screening with the Echo Liquid Handler
- Low-pH profiling in µL-scale to optimize protein production in H. polymorpha using the BioLector
- Optimized NGS Library Preparation with Acoustic Liquid Handling
- Preparation of Mouse Plasma Microsamples for LC-MS/MS Analysis Using the Echo Liquid Handler
- Protocols for use of SuperNova v428 conjugated antibodies in a variety of flow cytometry applications
- Robust and High-Throughput SARS-CoV-2 Viral RNA Detection, Research, and Sequencing Using RNAdvance Viral and the OT-2 Platform
- Screening yeast extract to improve biomass production in acetic acid bacteria starter culture
- SWOFF The unrecognized yet indispensable sibling of FMO
- The scattered light signal: Calibration of biomass
- Utilization of the MicroClime Environmental Lid to Reduce Edge Effects in a Cell-based Proliferation Assay
- Vertical Rotor Case Study with Adenovirus
- Whole Genome Sequencing of Microbial Communities for Scaling Microbiome and Metagenomic Studies Using the Echo 525 Liquid Handler and CosmosID
- Accurate enumeration of phytoplankton using FCM
- Accurately measures fine bubble size and particle count
- Anaerobe Kultivierung von probiotischen Bakterien imBioLectorXTMikrobioreaktor
- Anaerobe Kultivierung von probiotischen Bakterien im BioLector XT Mikrobioreaktor
- Assay Assembly for Miniaturized Quantitative PCR in a 384-well Format Using the Echo Liquid Handler
- Automated Solid Phase Extraction Based Determination of Cannabinoids
- Automated Transfection Methods
- Automating a Linear Density Gradient for Purification of a Protein:Ligand Complex
- Automation of Illumina DNA Prep Kit on Biomek NGeniuS Next Generation Library Prep System
- Biomek Automated Genomic Sample Prep Accelerates Research
- Biomek i-Series Automated AmpliSeq for Illumina® Library Prep Kit
- Biomek i-Series Automated Beckman Coulter Agencourt RNAdvance Blood Kit
- Biomek i-Series Automated Beckman Coulter Agencourt RNAdvance Cell
- Biomek i-Series Automated Beckman Coulter Agencourt SPRIselect for DNA Size Selection
- Control of Spheroid Size and Support for Productization
- Data-integrity-and-met-one-3400-plus-function-for-pharma
- Cultivation of Mammalian Cells in the Cydem VT System Bioreactor Module
- Cydem VT Automated Clone Screening System – Generating an Antibody Standard Curve
- Detection of Coarse Particles in Silica Causing Cracks in Semiconductor Encapsulants
- Effective Miniaturization of Illumina Nextera XT Library Prep for Multiplexed Whole Genome Sequencing and Microbiome Applications
- Efficient clone screening with increased process control and integrated cell health and titer measurements with the Cydem VT Automated Clone Screening System
- High-throughput IgG quantitation platform for clone screening during drug discovery and development
- Increased throughput for IgG quantification using Valita Titer 384-well plates
- Introducing the Cydem VT Automated Cell Culture System: A high-throughput platform for fast and reliable clone screening experiments
- Mixed Mode Sorting on the CytoFLEX SRT
- Modular DNA Assembly of PIK3CA Using Acoustic Liquid Transfer in Nanoliter Volumes
- Nanoliter Scale DNA Assembly Utilizing the NEBuilder HiFi Cloning Kit with the Echo 525 Liquid Handler
- Performance of the Valita Aggregation Pure assay vs HPLC-SEC
- Anaerobe Kultivierung von probiotischen Bakterien imBioLectorXTMikrobioreaktor
- Precision measurement of adipocyte size with Multisizer4e
- Principles of Continuous Flow Centrifugation
- Purifying High Quality Exosomes using Ultracentrifugation
- Quality Control of Anti-Blocking Powder Particle Size
- Rapid Rabbit IgG Quantification using the Valita Titer Assay
- Leveraging the Vi-CELL MetaFLEX for Monitoring Cell Metabolic Activity
- Unveiling the Hidden Signals: Overcoming Autofluorescence in Spectral Flow Cytometry Analysis
- Unlocking Insights: The Vital Role of Unmixing Algorithms in Spectral Flow Cytometry
- Vaporized Hydrogen Peroxide Decontamination of Vi–CELL BLU Instrument
- Automating the Valita Titer IgG Quantification Assay on a Biomek i-Series Liquid Handling System
- Viral Vector Purification with Ultracentrifugation
- Analytical Ultracentrifugation (AUC) for Characterization of Lipid Nanoparticles (LNPs): A Comprehensive Review
- Leveraging Analytical Ultracentrifugation for Comprehensive Characterization of Lipid Nanoparticles in Drug Delivery Systems
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Broschüren, Flyer und Datenblätter
- Access Single Robot System for Synthetic Biology Workflows
- Automated Solutions for Cell Line Development
- Automated Solutions for ELISA
- Echo Acoustic Liquid Handling for Synthetic Biology
- HIAC 8011+ Liquid Particle Counting Systems
- HIAC 9703+ Sub-Visible Particulate Testing
- LS 13 320 XR - Laser Diffraction Particle Size Analyzer
- Download the Valita Titer Assay Brochure
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Fallstudien
- Adenoviral Vectors Preparation
- Algae Biofuel Production
- Antibody and Media Development
- Autophagy
- B Cell Research
- Basic Research on Reproductive Biology
- Cardiovascular Disease Research
- Cell Marker Analysis
- Choosing a Tabletop Centrifuge
- Collagen Disease Treatment
- Contribute To Society By FCM
- Controlling Immune Response
- Creating Therapeutic Agents
- DNA Extraction from FFPE Tissue
- English Safety Seminar
- Equipment Management
- Exosome Purification Separation
- Fast, Cost-Effective and High-Throughput Solutions for DNA Assembly
- Future of Fishing Immune Research
- Hematopoietic Tumor Cells
- High-throughput next-generation DNA sequencing of SARS-CoV-2 enabled by the Echo 525 Liquid Handler
- Hiroshima Genbaku HP Hematopoietic Tumor Testing
- iPS Cell Research
- Leveraging acoustic and tip-based liquid handling to increase throughput of SARS-CoV-2 genome sequencing
- Membrane Protein Purification X Ray Crystallography
- Organelles Simple Fractionation
- Particle Interaction
- Quality evaluation of gene therapy vector
- Retinal Cell Regeneration
- Sedimentary Geology
- Severe Liver Disease Treatment
- Tierra Biosciences reveals major molecular discovery
- Treating Cirrhosis
- University Equipment Management
- University of Texas Medical Branch UTMB Workflow Comparison Study with the AQUIOS CL Flow Cytometer
- Fundamentals of Ultracentrifugal Virus Purification
- Catalogs
- Flyers
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Interviews
- Background and Current Status of the Introduction of Flow Cytometers
- Bacteriological-measurements-of-soil-bacteria-in-paddy-fields
- Benefits-of-the-coulter-principle-in-the-manufacturing-for-ips-cell-derived-natural-killer-cells
- Central Diagnosis in the Treatment of Childhood Leukemia 1
- Central Diagnosis in the Treatment of Childhood Leukemia 2
- Challenges-in-viability-cell-counting
- Contribution of Cytobank to 1-cell analysis of the cancer microenvironment
- Development of technology for social implementation of synthetic biology
- Flow Cytometry Testing in Hospital Laboratories
- Fundamentals of Ultracentrifugal Virus Purification
- Tumor Suppressor Gene p53 research and DNA Cleanup Process
- Fundamentals of Ultracentrifugal Virus Purification
- Dr Yabui UCF Lecture
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Posters
- Applications of Ultracentrifugation in Purification and Characterization of Biomolecules
- Automating Genomic DNA Extraction from Whole Blood and Serum with GenFind V3 on the Biomek i7 Hybrid Genomic Workstation
- ABRF 2019: Automated Genomic DNA Extraction from Large Volume Whole Blood
- Automated library preparation for the MCI Advantage Cancer Panel at Miami Cancer Institute utilizing the Beckman Coulter Biomek i5 Span-8 NGS Workstation
- Automating Cell Line Development for Biologics
- Cellular Challenges: Taking an Aim at Cancer
- Cell-Line Engineering
- Characterizing the Light-Scatter Sensitivity of the CytoFLEX Flow Cytometer
- AACR 2019: Isolation and Separation of DNA and RNA from a Single Tissue or Cell Culture Sample
- Mastering Cell Counting
- Preparing a CytoFLEX for Nanoscale Flow Cytometry
- A Prototype CytoFLEX for High-Sensitivity, Multiparametric Nanoparticle Analysis
- ABRF 2019: Simultaneous DNA and RNA Extraction from Formalin-Fixed Paraffin Embedded (FFPE) Tissue
- Quantification of AAV Capsid Loading Fractions: A Comparative Study
- Using Standardized Dry Antibody Panels for Flow Cytometry in Response to SARS-CoV2 Infection
- Product Instructions
- Experimental Protocols
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Whitepapers
- Centrifugation is a complete workflow solution for protein purification and protein aggregation quantification
- AUC Insights - Analysis of Protein-Protein-Interactions by Analytical Ultracentrifugation
- A General Guide to Lipid Nanoparticles
- Addressing issues in purification and QC of Viral Vectors
- GMP-Reinraumklassifizierung und Routine-Umgebungsüberwachung
- Purification of Biomolecules by DGUC
- AUC Insights - Assessing the quality of adeno-associated virus gene therapy vectors by sedimentation velocity analysis
- AUC Insights - Sample concentration in the Analytical Ultracentrifuge AUC and the relevance of AUC data for the mass of complexes, aggregation content and association constants
- Analyzing Biological Systems with Flow Cytometry
- Changes to USP <1788> Subvisible Particulate Matter
- Changes to USP <643> Total Organic Carbon
- Charakterisierung des RNAdvance Viral XP-RNS-Extraktionskits unter Verwendung von AccuPlex™ SARS-CoV-2 Referenz-Materialkit
- CytoFLEX Platform Flow Cytometers with IR Laser Configurations: Considerations for Red Emitting Dyes
- Evaluation of the Analytical Performance of the AQUIOS CL Flow Cytometer in a Multi-Center Study
- Simultaneous Isolation and Parallel Analysis of gDNA and total RNA for Gene Therapy
- Hydraulic Particle Counter Sample Preparation
- Inaktivierung des COVID-19-Krankheitsvirus SARS-CoV-2 mit Lysepuffern zur viralen RNA-Extraktion von Beckman Coulter
- Tips for Cell Sorting
- Liquid Biopsy Cancer Biomarkers – Current Status, Future Directions
- MET ONE 3400+ IT Implementation Guide
- Reproducibility in Flow Cytometry
- Improve the Efficiency of Large Scale Centrifugation
- SuperNova v428: New Bright Polymer Dye for Flow Cytometry
- Japan Document
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Application Notes